COOK COUNTY BUREAU OF HEALTH
SERVICES
GRANTS NEWSLETTER
Volume 7, Number 5 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~May,
1999
Back Issues
Published by
OFFICE OF RESEARCH DEVELOPMENT
Hektoen Building
627 South Wood Street
Chicago, IL 60612
FAX: 312-738-3102
Karen M. Smith, PhD, Director
312-633-4940
email: kmsmith@wwa.com
Bennetta Anderson, Administrative Assistant
312-633-4941
Lillian Hampton, IRB Administrator
312-633-7792
email: lhampton@hektoen.org
Funeka Sihlali, RN, Scientific Quality Coordinator
312-572-3506
email: fsihlali@hektoen.org
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COOK COUNTY BOARD
OF
COMMISSIONERS
John H. Stroger, Jr.,
President
|
Jerry
Butler
Allan C. Carr
Earlean Collins
John P. Daley
Gregg Goslin
Carl R. Hansen
Ted Lechowicz
Roberto Maldonado |
William R. Moran
Joseph Mario Moreno
Mike Quigley
Herbert T. Schumann, Jr.
Peter N. Silvestri
Deborah Sims
Bobbie L. Steele
Calvin R. Sutker |
COOK COUNTY BUREAU OF HEALTH
SERVICES
Ruth M. Rothstein, Chief
Affiliates
Ambulatory & Community Health Network
of Cook County
Cermak Health Services of Cook County
Cook County Department of Public Health
Cook County Hospital
Oak Forest Hospital of Cook County
Provident Hospital of Cook County
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FEDERAL REGULATORS SHUT DOWN MAJOR RESEARCH PROGRAMS
On May 12, the federal Office for Protection from Research Risks (OPRR)
suspended all federally funded research at the Duke University Medical
Center. With around $175 million in federal research funding, and about
$225 million in overall research funding, Duke has the eighth largest medical
research program in the country.
The OPRR cited a number of serious problems in the way Duke's Institutional
Review Board (IRB) operated. According to a story in the Raleigh, North
Carolina, News and Observer, the deficiencies cited include:
* The IRB violated rules that prevent IRB members from reviewing projects
in which they have a potential interest. After regulators ordered that
members of one Duke office not vote on certain projects, it twice found
in the board's minutes that they had.
* During the site visit, regulators determined that the IRB "regularly
failed to conduct substantive and meaningful continuing review of research."
Later they found that the board's record-keeping was inadequate to figure
out whether the problems had been fixed.
* Regulators could find "no evidence" the IRB made all the determinations
that it should while reviewing research involving children.
* During the site visit, regulators found documents used to obtain consent
from patients that significantly deviated from regulatory requirements.
Duke administrators failed to correct the situation.
* The IRB had no full-time person in charge, despite Duke's assurances
that it would find someone. IRB staffing was inadequate.
The Washington Post in its May 12 edition quoted Gary Ellis, Director
of OPRR as saying,"When OPRR identified serious deficiencies in protecting
human subjects in December 1998 at Duke University Medical Center, we believed
that the university would move quickly to remedy them. It was disappointing
to see a protracted and unsatisfactory response."
According to the Post story, "Others, however, said they suspected
that the OPRR's action was also motivated in part by a need to prove its
mettle to Congress in the wake of recent allegations by patient groups
and others that the government is failing to protect research subjects."
This is the second time in 1999, and the third time in the past nine
months, that OPRR has totally suspended a major research program for failing
to adequately protect human subjects. In March the research program at
the largest Veteran's Administration Hospital in the country, in West Los
Angeles, was similarly suspended, as was that at Rush-Presbyterian-St.Luke's
Medical Center last fall. Previous to those suspensions, the only time
OPRR had ever suspended an entire institutional research program was in
1990.
Some of the allegations mentioned in the Post article cited above came
from a report issued in 1998 by the Inspector General of the Department
of Health and Human Services, which concluded that the current IRB system
has a number of serious weaknesses, including the expectation that IRB's
will review too much, too quickly and with too little expertise; minimal
review of research after approval; conflicts of interest among IRB members;
and lack of adequate training for investigators and IRB members. In a similar
vein, the National Bioethics Advisory Commission has asserted that the
current IRB system needs additional procedural safeguards to protect persons
with limited decisional capacity such as those who are mentally ill.
In light of the intense scrutiny research and IRB's are currently receiving,
the institutions of the Cook County Bureau of Health Services have undertaken
a thorough review and revision of research policies and practices, with
an eye toward establishing and maintaining Bureau-wide research standards.
The goal is to ensure and document-- that research taking place anywhere
in the system meets the highest possible ethical standards, and that both
investigators and IRB members are equipped to meet those standards. As
will be described in future Newsletters, a new program of Scientific Quality
Assurance is being implemented by the Office of Research Development to
help achieve this goal.
CYBERETHICS: ONLINE RESOURCES
Sites are being established all over the World Wide Web to foster discussion
and dissemination of information about ethics, particularly in regard to
science and research. A central source with links to many of these is offered
by the Poynter Center at the University of Indiana at www.indiana.edu/~poynter/index.html
Those with an interest in the legal and ethical issues surrounding protection
of human research subjects can visit the OPRR site at http://www.nih.gov:80/grants/oprr/oprr.htm
and the one maintained by Public Responsibility in Medicine and Research
(PRIM&R) at http://www.aamc.org/research/primr/
In addition, a "virtual symposium" on twentieth century values inquiry
is being held until May 21 at http://cape.cmsu.edu/scripts/lyris.pl
Rush University Research Forum Schedule
May 18- 20, 1999
Room 500, Searle Conference Center
[NOTE TO POSTER EXHIBITORS: Poster number assignments and directions
for participants may be found at www.rush.edu/rushforum. If you have additional
questions, send email to fhughes@rush.edu]
May 18:
Symposium, Noon - 1:00 PM
Poster Viewing, 1:00 - 5:00 PM
May 19:
Symposium, Noon - 1:00 PM Poster Viewing & Student Poster Judging,
1:00 - 5:00 PM
May 20:
Symposium, Noon - 1:00 PM College Award Talks, 1:00 -2:00 PM
Resident & Fellows Forum, 2:00-4:00 PM
Poster Tours, 4:00 - 6:00 PM
Symposia:
Tissue Replacement in the Next Millennium
Tuesday, May 18, 1999
12:00 noon - 1:00 p.m.
Room 540Chair: Tina Hieken, M.D., Department of General Surgery, Rush
North Shore Medical Center
"Xenotransplantation: Replacement parts for the 21st century" Verdi
J. DiSesa, M.D., Department of Cardiovascular - Thoracic Surgery, Surgical
Director, Rush Heart Institute
"Bone marrow transplantation - the changing treatment" Hans Klingemann,
M.D., Ph.D. Section of Bone Marrow Transplantation, The Rush Cancer Institute
Degenerative Joint Disease: Wear and Tear in Our Aging Society
Wednesday, May 19, 1999
12:00 noon - 1:00 p.m.
Room 540Chair: Joel Block, M.D., Section of Rheumatology, Department
of Medicine Rush-Presbyterian-St.Luke's Medical Center
"Osteoarthritis in human knee and ankle joints: biochemical not just
biomechanical initiators" Ada Cole, Ph.D. Department of Biochemistry
"De and Regeneration of the intravertebal discs" Howard An, M.D., Department
of Orthopedic of Surgery
Protecting Families in the Next Millennium
Thursday, May 20, 1999
12:00 noon-1:00 p.m.
Room 976Chair: M. Ramez Salem, M.D., Department of Anesthesiology,
Illinois Masonic Medical Center
"Research using a psychoeducational program for parents raising the
next generation" Deborah Gross, DNSc, RN, FAAN, Departments of Community
& Mental Health Nursing
"The epidemiology of handgun violence"
Rob Smith, M.D., Department of Trauma
Cook County Hospital
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SEMINARS, CONFERENCES, WORKSHOPS, ETC
[A long-term calendar showing most of the major academic medical society
meetings can be found on the web at: http://www.aamc.org/meetings/mjmtgcal.htm]
Workshop on Teaching Academic Survival Skills and Ethics, offered by
The University of Pittsburgh, will be held June 6-11. Call 412-624-7098
for details.
Health Profession Analysis for Primary Care, a conference on health
workforce issues, will be held June 3 and 4 in San Francisco, sponsored
in part by the Health Resources and Services Administration. For more information
call 301-443-3148.
Spirituality, Cross-Cultural Issues and End of Life Care, will be offered
by AAMC and the National Institute for Healthcare Research September 24-25
in Denver. Call 301- 984-7162 for information.
Ethical Issues in International Health Research will take place June
14-18 at Harvard School of Public Health, Center for Continuing Professional
Education.
Also, Measurement, Design and Analysis Methods for Health Outcomes
Research will be offered June 15-18. For more information call617-432-1171.
Office of Research Development Workshops
These workshops are open to any County-affiliated investigator or grant-seeker.
Enrollment for some sessions is limited, so please register only for those
you will be able to attend.
Grant Writing Seminar:
Gives an overview of the entire process of developing a project
and applying for funding. Includes information on approaching both governmental
and private funders, describes an approach to developing grant budgets,
discusses stylistic and content issues that are frequent stumbling blocks
in writing grant applications.
Constructing a Grant Budget:
Covers many of the technical aspects of developing an accurate
time line and budget for a grant proposal.
What Are All These Forms? Interacting With the Scientific Committee:
Gives an orientation to procedures -- and the associated forms
-- used by the Scientific Committee to
ensure that patients are protected from undue risks in research. The
Bureau forms will be discussed, and new policies and changes in federal
regulations will be covered.
To register for any of these, call Bennetta Anderson at 312-633-4941.
If you would like to schedule one or more of these workshops in your Department
or at another site, please call Karen Smith at 633-4940.
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FUNDING OPPORTUNITIES
National Institutes of Health:
All NIH announcements from the past several years, including full
text versions of RFA's and PA's, can be reached on the web at: http://grants.nih.gov/grants/guide/index.html
To have the NIH Guide sent automatically to your e-mail address every
week, click on the LISTSERV link on this page and follow the instructions.
To ask specific questions about NIH grant programs, send e-mail to:
grantsinfo@nih.gov
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NIH RFA'S AND RFP'S:
These are one time only opportunities. Call 312-633-4940 to check
for due dates or to get copies of full announcements
DEVELOPMENT OF MOUSE PHENOTYPIC SCREENS FOR HEART, LUNG, AND BLOOD
DISEASES (RFA-HL-99-010) National Heart, Lung, and Blood Institute
PROTEIN STRUCTURE AND FUNCTION IN AGING & LATE-LIFE DISEASE (RFA-AG-99-005)
National Institute on Aging
NATIONAL COOPERATIVE DRUG DISCOVERY GROUPS (RFA-CA-99-010) National
Cancer Institute
ENVIRONMENTAL JUSTICE: PARTNERSHIPS FOR COMMUNICATION (RFA-ES-99-005)
National Institute of Environmental Health Sciences
MENTAL RETARDATION RESEARCH CENTERS (RFA-HD-99-004) National Institute
of Child Health and Human Development
MEDICAL REHABILITATION RESEARCH NETWORKS (RFA-HD-99-006) National Institute
of Child Health and Human Development
THROMBOSIS OF THE ARTERIAL AND CEREBRAL VASCULATURE: NEW MOLECULAR GENETIC
CONCEPTS FOR PREVENTION AND TREATMENT (RFA-HL-99-015) National Heart, Lung,
and Blood Institute, National Institute of Neurological Disorders and Stroke
MECHANISTIC-BASED CANCER RISK ASSESSMENT METHODS (RFA-OH-99-003)
National Institute for Occupational Safety and Health, National Center
for Environmental Research and Quality Assurance, National Cancer Institute
ALCOHOL RESEARCH CENTER GRANTS
(RFA-AA-99-005) National Institute on Alcohol Abuse and Alcoholism
MECHANISMS OF CHONDROPROTECTION
(RFA-AR-99-004) National Institute of Arthritis and Musculoskeletal
and Skin Diseases
INTERNET CONNECTION FOR HEALTH INSTITUTIONS (RFA-LM-99-001) National
Library of Medicine
NIMH COLLABORATIVE HIV/STD PREVENTION TRIAL (RFA-MH-99-011) National
Institute of Mental Health
EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN-VITRO TECHNIQUES (RFP
N01-CN-85093-63) National Cancer Institute
MEDICATION DISCOVERY USING RAT MODELS OF RELAPSE TO COCAINE
SELF-ADMINISTRATION (RFP N01DA-9-8096) National Institute on Drug Abuse
PREPARATION AND DISTRIBUTION OF RESEARCH DRUG PRODUCTS (RFP
N01DA-9-7074) National Institute on Drug Abuse
SILVIO O. CONTE DIGESTIVE DISEASES RESEARCH CORE CENTERS (RFA-DK-99-017)
National Institute of Diabetes and Digestive and Kidney Diseases
COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
(RFA-HD-99-005) National Institute of Child Health and Human Development
EXPLORATORY PROJECTS FOR LONGITUDINAL GENETIC EPIDEMIOLOGIC STUDIES
ON AGING (RFA-AG-99-007)
National Institute on Aging, National Institute of Environmental Health
Sciences
COOPERATIVE PROSTATE CANCER TISSUE RESOURCE (RFA-CA-99-012) National
Cancer Institute
STUDIES OF THE ETHICAL, LEGAL AND SOCIAL IMPLICATIONS OF RESEARCH INTO
HUMAN GENETIC VARIATION (RFA-HG-99-002) National Human Genome Research
Institute, National Institute on Deafness and Other Communication Disorders,
National Institute of Environmental Health Sciences, National Institute
of General Medical Sciences
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NIH PROGRAM ANNOUNCEMENTS
(PA'S): These are ongoing funding priorities, with due dates usually
October 1, February 1 and June 1 of each year. Note that HIV-related applications
are due January 2, May 1 and September. Past PA's, many of which are still
open, can be searched at the NIH
Guide web site.
NCI TRANSITION CAREER DEVELOPMENT AWARD (K22) (PAR-99-094) National
Cancer Institute
CANCER EDUCATION AND CAREER DEVELOPMENT PROGRAM (PAR-99-095)
National Cancer Institute
MECHANISMS UNDERLYING SECONDARY CONDITIONS IN MOBILITY DISORDERS
(PA-99-096) National Institute of Child Health, and Human Development,
National Institute on Aging, National Institute of Arthritis and Musculoskeletal
and Skin Diseases, National Institute of Diabetes and Digestive and Kidney
Diseases, National Institute of General Medical Sciences, National Institute
of Nursing Research
DIVERSITY IN MEDICATION USE AND OUTCOMES IN AGING POPULATIONS
(PA-99-097) National Institute on Aging, National Center for Complementary
and Alternative Medicine, Office of Research on Minority Health, Office
of Research on Women's Health
NIAAA SMALL GRANT PROGRAM (PAR-99-098) National Institute on Alcohol
Abuse and Alcoholism
NIAMS SMALL GRANT PROGRAM FOR NEW INVESTIGATORS (PAR-99-099) National
Institute of Arthritis and Musculoskeletal and Skin Diseases
NIA PILOT RESEARCH GRANT PROGRAM
(PA-99-049) National Institute on Aging
CLINICAL INTERVENTIONS FOR MANAGING THE SYMPTOMS OF STROKE (PA-99-088)
National Institute of Nursing Research, National Institute of Neurological
Disorders and Stroke, National Institute on Aging, National Institute on
Deafness and Other Communication Disorders, National Institute of Child
Health and Human Development
INDIVIDUAL PREDOCTORAL NATIONAL RESEARCH SERVICE AWARDS FOR M.D./PH.D.
FELLOWSHIPS (PA-99-089) National Institute of Mental Health, National Institute
on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, National
Institute of Environmental Health Sciences
PREVENTION AND EARLY INTERVENTION IN PSYCHOTIC DISORDERS (PA-99-090)
National Institute of Mental Health
MINORITY ACCESS TO RESEARCH CAREERS (MARC) ANCILLARY TRAINING
ACTIVITIES GRANTS (PAR-99-091)
National Institute of General Medical Sciences
INNOVATION GRANT PROGRAM: APPROACHES IN HIV VACCINE RESEARCH - UPDATE
(PA-98-075) National Institute of Allergy and Infectious Diseases
DEVELOPMENT OF DIGITAL MAMMOGRAPHY DISPLAYS AND WORKSTATIONS (PA-99-082)
National Cancer Institute
DEVELOPMENT OF DIGITAL MAMMOGRAPHY DISPLAYS AND WORKSTATIONS (SBIR/STTR)
(PA-99-083) National Cancer Institute
SBIR/STTR STUDY AND CONTROL OF MICROBIAL BIOFILMS (PA-99-084) National
Institute of Dental and Craniofacial Research, National Heart, Lung, and
Blood Institute, National Institute of Allergy and Infectious Diseases,
National Institute on Deafness and Other Communication Disorders, National
Institute of Arthritis and Musculoskeletal and Skin Diseases, National
Institute of General Medical Sciences, National Institute of Diabetes and
Digestive and Kidney Diseases, National Institute of Child Health and Human
Development, National Institute of Neurological Disorders and Stroke, National
Institute of Nursing Research, Office of Research on Women's Health
BONE AND THE HEMATOPOIETIC AND IMMUNE SYSTEMS (PA-99-085) National Institute
of Arthritis and Musculoskeletal and Skin Diseases, National Institute
on Aging, National Institute of Dental and Craniofacial Research, National
Institute of Diabetes and Digestive and Kidney Diseases, National Heart,
Lung, and Blood Institute
NOVEL APPROACHES TO ENHANCE STEM CELL RESEARCH (PA-99-086) National
Center for Research Resources, National Heart, Lung and Blood Institute,
National Institute of Child Health and Human Development, National Institute
of Diabetes and Digestive and Kidney Diseases, National Institute of Mental
Health
MENTORED QUANTITATIVE RESEARCH CAREER DEVELOPMENT AWARD
(PA-99-087) National Heart, Lung, and Blood Institute, National Human
Genome Research Institute, National Institute on Aging, National Institute
on Alcohol Abuse and Alcoholism, National Institute of Allergy and Infectious
Diseases, National Institute of Arthritis and Musculoskeletal and Skin
Diseases, National Institute of Child Health and Human Development, National
Institute on Deafness and Other Communication Disorders, National Institute
of Dental and Craniofacial Research, National Institute of Diabetes and
Digestive and Kidney Diseases, National Institute on Drug Abuse, National
Institute of Environmental Health, Sciences, National Institute of General
Medical Sciences, National Institute of Mental Health, National Institute
of Neurological Disorders and Stroke
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OTHER OPPORTUNITIES
June 24
CHILDREN AT RISK OF EMOTIONAL DISTURBANCE: TECHNICAL CENTER, Substance
Abuse and Mental Health Services Administration (301-443-1333)
June 18
RESEARCH IN POST-TRANSPLANT COMPLICATIONS, The Marrow Foundation (612-632-3425)
June 24
COMMUNITY FOOD PROJECTS, US Department of Agriculture (202-401-1898
or http://www.reeusda.gov)
July 1
RESEARCH ON FAMILY MEDICINE, American Academy of Family Physicians
Foundation (800-274-2237, x4470 or http://www.aafp.org)
July 12
MODEL ORGAN DONOR PROGRAMS, Health Resources and Services Administration
9301-443-7577 or http://www.hrsa.gov)
June 2
EVALUATION STUDIES ON VIOLENCE AGAINST WOMEN, National Institute of
Justice (800-851-3420 or http://www.ncjrs.org/fedgrant.htm#nij)
June 1
SAFE SCHOOLS, Health and Human Services, Department of Education, Department
of Justice (http://www.mentalhealth.org)
June 14
SAFE START (VIOLENCE PREVENTION & EARLY CHILDHOOD DEVELOPMENT),
Department of Justice (202-514-5084)
October 31
ALTERNATIVE REFUGEE ASSISTANCE, Administration for Children and Families
(202-401-4558)
June 1
HIV/AIDS SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE, Health Resources
and Services Administration (301-443-5650 or http://www.hrsa.dhhs.gov)
June 1
EMERGENCY MEDICAL SERVICES FOR CHILDREN, Health Resources and Services
Administration (301-443-6192 or http://www.hrsa.dhhs.gov)
June 30
HEALTH COMMUNICATION, Centers for Disease Control and Prevention(404-639-7275,
or http://www.cdc.gov)
July 1
EDUCATIONAL PROGRAMS IN OCCUPATIONAL HEALTH, Centers for Disease Control
and Prevention(513-533-8241, or http://www.cdc.gov)
June 30
YOUNG WORKER SAFETY, Centers for Disease Control and Prevention(304-285-6012,
or http://www.cdc.gov)
July 1, November 1
CAREER AND SMALL GRANTS IN OCCUPATIONAL HEALTH RESEARCH, NIOSH/ Centers
for Disease Control and Prevention (404-639-3343 or http://www.nih.gov/grants/guide/index.html,
refer to PAS 99-053)
May 21(letter of intent)
ACADEMIC DIGITAL INFORMATION & PUBLISHING PROJECTS, Scholarly Publishing
and Academic Resources Coalition (202-296-2296 or http://www.arl.org/sparc)
July 31
AWARDS FOR EXCEPTIONAL WORK, Rolex Awards for Enterprise (http://www.rolexawards.com)
June 30
HEALTH INTERVENTIONS IN THE CONSTRUCTION INDUSTRY, Centers for Disease
Control and Prevention(513-841-4493, or http://www.cdc.gov)
June 1 and December 1
SPINAL CORD INJURY/DYSFUNCTION, Paralyzed Veterans of America (800-424-8200,
x655 or http://frontpage.pva.inter.net/prof/etfgd/index.htm)
June 2 (letter of intent) July 6 (application)
CENTERS FOR EXCELLENCE IN HEALTH STATISTICS, Centers for Disease Control
and Prevention(301-436-7016, or http://www.cdc.gov/nchswww)
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