IRB, Office of Research Development COOK COUNTY BUREAU OF HEALTH SERVICES
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COOK COUNTY BUREAU OF HEALTH SERVICES

GRANTS NEWSLETTER



Volume 6, Number 1 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~January, 1998
Back Issues

Published by
OFFICE OF RESEARCH DEVELOPMENT
Hektoen Building
627 South Wood Street
Chicago, IL 60612
FAX: 312-738-3102

Karen M. Smith, PhD, Director
312-633-4940
email: kmsmith@wwa.com
Bennetta Anderson, Administrative Assistant
312-633-4941
Lillian Hampton, IRB Administrator
312-633-7792
email:  lhampton@hektoen.org
Funeka Sihlali, RN, Scientific Quality Coordinator
312-572-3506
email:  fsihlali@hektoen.org

COOK COUNTY BOARD OF
COMMISSIONERS
John H. Stroger, Jr., President
  Jerry Butler 
  Allan C. Carr
  Earlean Collins
  John P. Daley
  Gregg Goslin 
  Carl R. Hansen
  Ted Lechowicz 
  Roberto Maldonado
 William R. Moran
 Joseph Mario Moreno 
 Mike Quigley
 Herbert T. Schumann, Jr.
 Peter N. Silvestri 
 Deborah Sims
 Bobbie L. Steele 
 Calvin R. Sutker
COOK COUNTY BUREAU OF HEALTH
SERVICES 
Ruth M. Rothstein, Chief
Affiliates
Ambulatory & Community Health Network 
of Cook County
Cermak Health Services of Cook County
Cook County Department of Public Health
Cook County Hospital 
Oak Forest Hospital of Cook County 
Provident Hospital of Cook County

COOK COUNTY RESEARCH WELL-REPRESENTED IN FORUM
 

More than 50 of the approximately 230 posters to be exhibited at the annual Rush University Research Forum will be those of Cook County investigators. An additional 16 will represent research carried out jointly at Cook County Hospital and Rush.

Posters will be displayed February 25 through 27 in the Searle Conference Center, 5th floor of the Rush Professional Building. A series of symposia will also be held on these days in Room 540 of the Rush Academic Facility. The schedule for these sessions is given below.

This forum is always a good opportunity for investigators to meet colleagues from affiliated institutions and to catch up on recent local research. You're welcome to drop by to view the posters any of the three days until 5:00 pm. A poster-viewing reception will be held on Friday from 3:00 to 5:00 pm.
 



Wednesday, February 25, 1998
12:00 noon - 1:30 p.m.
 
"Role of Nutrition in Health and Disease Prevention"

Chair: Ann Minnick, Ph.D., R.N., FAAN
Associate Dean - Research, Rush College of Nursing 

Anatoly Bezkorovainy, Ph.D. Department of Biochemistry, Rush Medical & Graduate College
"Health Benefits of Fermented Milk Product Bacteria"

Paula Meier, R.N., DNSc, FAAN, Department of Maternal Child Nursing, Rush College of Nursing
"Lactoengineering Mother's Own Milk for Very Small Preterm Infants"
Christine Tangney, Ph.D., Department of Clinical Nutrition, Rush College of Health Sciences "Vitamin E: Help or Harm?"
 



Thursday, February 26, 1998
12:00 noon - 1:30 p.m.
 
"Studies of Problems in the Aging Population"

Chair: Steven Rothschild, M.D. Department of Family Medicine, Illinois Masonic Medical Center

Denis Evans, M.D. Rush Institute on Healthy Aging & Department of Internal Medicine, Rush Medical College "The Chicago Health and Aging Project"

Diane Cronin-Stubbs, Ph.D., R.N., FAAN
Department of Psychiatric & Gerontological Nursing Rush College of Nursing "Health Effects of Mild Depression in Aging"

Philip Gorelick, M.D. Department of Neurological Sciences, Rush Medical College "Stroke in the High Risk Elderly"
 



Friday, February 27, 1998
12:00 noon-1:30 p.m.
 
"Women's Health Issues"
 

Chair: Brendan Reilly, M.D. Combined Cook County/Rush Grand Rounds Department of Medicine, Cook County Hospital

Ellen Mason, M.D. Departments of Medicine and OB/Gyn, Cook County Hospital
"Pregnant, Parenting, Chemically Dependent: Results of an Analysis of a Comprehensive Women's Addiction Treatment Program"

Lynda Powell, Ph.D. Department of Preventive Medicine, Rush Medical College "The Natural History of the Menopausal Transition: a population perspective"

Henry Black, M.D. Department of Preventive Medicine, Section of Epidemiology, Rush Medical College "Women's Health Initiative"
 


NIH PEER REVIEW: HOW TO APPEAL

What if you submitted a grant application to NIH, and it received a review you consider totally off the mark? Do you have any recourse? NIH provides an applicant who feels that some aspect of the handling or peer review of his/her grant application has been inappropriate, biased, or wrong with an opportunity to have these concerns addressed. 
The following is a description of the NIH review appeals process, which was recently streamlined from a two-stage to one-stage procedure:

"The decision to fund a grant application lies with the particular NIH Institute or Center to which it has been assigned, and is based upon both (a) the results of the initial scientific peer review and (b) the recommendation of that Institute's National Advisory Council or Board. With regard to the initial review, after examining the summary statement containing the results of that review for the grant application, an investigator may have concerns about, and wish to contest a procedural aspect of the process (e.g., that the review was biased, that conflict of interest existed, that the review group lacked appropriate expertise, that factual errors entered into the review). 

"Because NIH is dedicated to maintaining the overall high quality of its peer review system and of the review of individual applications, it has established appeal procedures for investigators to address such concerns. However, the differences of scientific opinion that often occur between investigators and reviewers may not be contested through these procedures. In addition, communications from investigators consisting of additional information that was not available to the reviewers are not considered to be appeals.

"An investigator who is concerned about the review of his or her application should first contact the Program Administrator who has been assigned responsibility for the application (see contact information in the upper left hand corner of the first page of the summary statement). He or she is the key person for clarifying points in the summary statement or about the review process, and may be able to provide additional information beyond that which appears in the summary statement. 

"Often, the Program Administrator will recommend either revising the application, addressing the points raised in the review, and resubmitting it or reconsidering the basic intent of the proposed project and submitting a new application. (In either case, an investigator may request that it be reviewed by a specific review group via a cover letter submitted with the application.)

"However, if after discussion with the Program Administrator, the investigator still has concerns about procedural aspects of the review, he or she should submit a formal letter of appeal to the Program Administrator specifying the perceived flaws in the review. It is the Program Administrator's responsibility to handle the appeal and to do so according to specific appeal procedures. The Program Administrator will consult with the Scientific Review Administrator (SRA) who administered the review of the application, and this consultation could result in a decision to re-review the application. (A re-review consists of a review of the same application, not a revised version, by the same or another review group without access to the summary statement of the flawed review.) 

"However, if the investigator, Program Administrator, and SRA cannot agree on a course of action, then the appeal case will be reviewed by the Institute's Appeal Officer, a senior official not directly involved in peer review. The Institute will make the appeal letter available to the Council together with the staff's recommendation and any written comments from the SRA or review group. The Program Administrator and SRA have a responsibility to be available for the Council discussion of the appeal. 

"The Council has two usual options with regard to appeals: to recommend that the review stand (I. e., reject the appeal) or to recommend that the application be re-reviewed. Written documentation of the outcome of the Council's deliberations will be sent to the investigator, and the appeal letter and associated correspondence will be retained in the official file for the application. In sum , the key to resolution of situations where an investigator has concerns about the review of his or her application lies in discussion with the Program Administrator and, when appropriate, in submission of a appeal letter that. If not resolved by NIH staff, the appeal is presented for Council consideration and resolution. 

"The details of the appeal procedures used by the different Institutes may vary somewhat, but each provides a means for appeals to be given full consideration by staff and, if necessary, by the Council (or a subset of it). Additional information about an Institute's appeal procedures may be obtained from Program Administrators and, shortly, will also be available on the Institutes' home pages." 

From the NIH Guide to Grants and Contracts, November 21, 1997

If you are interested in knowing more about the entire NIH review process, or would like to know who currently sits on a particular review group, go to http://www.csr.nih.gov/refrev.htm on the World Wide Web.
 


RECENT PUBLICATIONS

The following are recent publications by investigators affiliated with the Cook County Bureau of Health Services.

Bracken J "Reducing door-to-needle time: treatment delay versus presentation delay."Clin Cardiol 1997 Nov;20(11 Suppl 3):III-III215

Cohen M "Natural history of HIV infection in women." Obstet Gynecol Clin North Am 1997 Dec;24(4):743-758

Coutinho R, David RJ, Collins JW Jr "Relation of parental birth weights to infant birth weight among African Americans and whites in Illinois: a transgenerational study." Am J Epidemiol 1997 Nov 15;146(10):804-809

Cohen RA, Muzaffar S, Schwartz D, Bashir S, Luke S, McGartland LP, Kaul K "Diagnosis of pulmonary tuberculosis using PCR assays on sputum collected within 24 hours of hospital admission." Am J Respir Crit Care Med 1998 Jan;157(1):156-;161

Glick RP, Lichtor T, Unterman TG "Insulin-like growth factors in central nervous system tumors." J Neurooncol 1997 Dec;35(3):315-325

Henderson CT, Ayello EA, Sussman C, Leiby DM, Bennett MA, Dungog EF, Sprigle S, Woodruff L "Draft definition of stage I pressure ulcers: inclusion of persons with darkly pigmented skin. NPUAP Task Force on Stage I Definition and Darkly Pigmented Skin." Adv Wound Care 1997 Sep;10(5):16-19

McDermott MF, Murphy DG, Zalenski RJ, Rydman RJ, McCarren M, Marder D, Jovanovic B, Kaur K, Roberts RR, Isola M, Mensah E, Rajendran R, Kampe L "A comparison between emergency diagnostic and treatment unit and inpatient care in the management of acute asthma."Arch Intern Med 1997 Oct 13;157(18):2055-2062

Ray P, Bhatti R, Gadarowski J, Bell N, Nasruddin S "Inhibitory effect of amiloride on the urokinase plasminogen activators in prostatic cancer." Tumour Biol 1998, 19(1):60-64

Sakurai M, Tanaka H, Matsuda T, Goya T, Shimazaki S, Matsuda H "Reduced resuscitation fluid volume for second-degree experimental burns with delayed initiation of vitamin C therapy." J Surg Res 1997 Nov;73(1):24-27
 


ANSWERS TO YOUR QUESTIONS

Where can I get copies of Federal grant application forms?

Where can I look for likely foundations to fund my project?

Where can I obtain the CCH guidelines for investigators?

The answer to all these and more is the Research Development Resource Room, 603 Durand. It's open from 8:00 am to 4:00 pm every business day.


DID YOU KNOW...

..that the average length of hospital stay in the Chicago metro area during the first quarter of 1997 was 4.6 days? That 12.5% of the Chicago population has no medical insurance? That the average wait for a first maternal appointment with a "safety net" provider in Chicago was 15 days in 1997? These facts are part of a "Chicago Health Scorecard" developed by the Chicago Health Policy Research Council to provide benchmarks for the overall performance of the area's health care system. The scorecard is presented in the first issue of the Chicago Health Care Report, a new quarterly publication of the Council. For more information about this organization and its publications, call 773-702-4335, or look at its website: http://www.chas.uchicago.edu.chprc

...that during 1992 to 1994, there was no prenatal care for nearly 7% of the 4110 births to mothers living in East Garfield Park, the Near West Side and North Lawndale? Health reports for all Chicago community areas can be found online at a site maintained by the Chicago Department of Public Health and the Metropolitan Chicago Information Center at: http://www.mcic.org/health/hcdph.html

...that according to the 1990 census, over 8,000 children aged 14 and under in the Near West Side area were living in a household headed by a single woman? That over a third of the female-headed households in this community area included children over the age of 18? For profiles of local demographics broken down by Chicago community area or by Illinois county, go to the website site maintained by the Geography Program at UIC at http://www.cagis.uic.edu/
The "quick report form" here can be used to pull up any number of useful demographic breakdowns of Chicago community areas based on the 1990 census.

..that Philadelphia has 26% more primary care physicians and 68% more specialists per capita than Minneapolis? That breast-sparing surgery for cancer is most common in the Northeast, and its use lowest in the South, Midwest, and Northwest? The Dartmouth Atlas of Health Care is based on extensive analyses of Medicare claims records, physician registries, hospital reporting information and other sources of information nationwide for the years 1992-93. The atlas presents a clear and detailed picture of health care across the nation, with data broken down by 3,436 local health care markets. Its development was funded by the Robert Wood Johnson Foundation, and it is now available in several forms -- CD-ROM, paper or diskette. Ordering information can be obtained from 1-800-AHA-2626, or on the Web at http://www.dartmouth.edu/~atlas/

..where to find national age-adjusted rates of death from hypertension, grouped by 10-year age intervals and by race/ethnicity? This is one of many unpublished tables of vital statistics and health-related information available online from the National Center for Health Statistics "Data Warehouse" at http://www.cdc.gov/nchswww/datawh/datawh.htm



CALL FOR ABSTRACTS

The Annual Conference on Research in Medical Education has issued a call for research papers, review papers, symposia and abstracts to be presented October 30-November 5, 1998 in New Orleans. The deadline is March 20. Submission forms can be obtained from the Office of Research Development.

 
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SEMINARS, CONFERENCES, WORKSHOPS, ETC 

[A long-term calendar showing most of the major academic medical society meetings can be found on the web at: http://www.aamc.org/meetings/mjmtgcal.htm
 

Chicago & Great Lakes Health Services Research Forum: The second annual meeting sponsored by local research entities will be held March 12-13 at the University of Chicago, Ida Noyes Hall. For more information call Carolyn Martin at 847-256-1359.

Spirituality, Cross-Cultural Issues and End of Life Care, sponsored by the National Institute for Healthcare Research and the American Association of Medical Colleges, will be held March 20-21 in Washington, DC.
For more information, call 301-984-7162.

Ethical Challenges in Managed Care - Advanced Bioethics Course offered by the Kennedy Institute of Ethics, will be held March 8-12 in Washington, DC. For more information call 202-687-6771. 

The Human Genome Project - Science, Law and Social Change in the 21st Century, sponsored by the Whitehead Institute for Biomedical Research, will take place April 23-24 in Cambridge, Massachusetts. Call 617-258-0633 for more information.

Contemporary Challenges in Health Care Ethics - Intensive Bioethics Course offered by the Kennedy Institute of Ethics, will be held June 7-12 in Washington, DC. For more information call 202-687-6771. 

Teaching Research Ethics Workshop will be given by the University of Indiana, Bloomington, Indiana, June 24-27. For information call 812-855-0261.
 

Office of Research Development Workshops 

These workshops are open to any County-affiliated investigator or grant-seeker. Enrollment for some sessions is limited, so please register only for those you will be able to attend. 

Grant Writing Seminar:

Gives an overview of the entire process of developing a project and applying for funding. Includes information on approaching both governmental and private funders, describes an approach to developing grant budgets, discusses stylistic and content issues that are frequent stumbling blocks in writing grant applications.


Constructing a Grant Budget:

Covers many of the technical aspects of developing an accurate time line and budget for a grant proposal.


What Are All These Forms? Interacting With the Scientific Committee

Gives an orientation to procedures -- and the associated forms -- used by the Scientific Committee to 
ensure that patients are protected from undue risks in research. The Bureau forms will be discussed, and new policies and changes in federal regulations will be covered.


To register for any of these, call Bennetta Anderson at 312-633-4941. If you would like to schedule one or more of these workshops in your Department or at another site, please call Karen Smith at 633-4940. 
 

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FUNDING OPPORTUNITIES

National Institutes of Health:
All NIH announcements from the past several years, including full text versions of RFA's and PA's, can be reached on the web at:  http://grants.nih.gov/grants/guide/index.html

To have the NIH Guide sent automatically to your e-mail address every week, click on the LISTSERV link on this page and follow the instructions.

To ask specific questions about NIH grant programs, send e-mail to: grantsinfo@nih.gov 
 



NIH RFA'S AND RFP'S: 

These are one time only opportunities. Call 312-633-4940 to check for due dates or to get copies of full announcements

DATA COORDINATION CENTER FOR THE NIH-DC INITIATIVE TO REDUCE INFANT MORTALITY IN MINORITY POPULATIONS (RFA HD-98-003) National Institute of Child Health and Human Development, Office of Research on Minority Health

DEVELOPING ALCOHOL-RELATED HIV PREVENTIVE INTERVENTIONS (RFA AA-98-001)
National Institute on Alcohol Abuse and Alcoholism

METHODS FOR DISCOVERING AND SCORING SINGLE NUCLEOTIDE POLYMORPHISMS 
(RFA HG-98-001) National Institutes of Health

WOMEN'S REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENT CENTERS
(RFA HD-98-004) National Institute of Child Health and Human Development, Office of Research on Women's Health

GENETIC MECHANISMS IN ORAL CANCER (RFA DE-98-008) National Institute of Dental Research

SILVIO O. CONTE DIGESTIVE DISEASES RESEARCH CORE CENTERS (RFA DK-98-012)
National Institute of Diabetes and Digestive and Kidney Diseases

MENTAL HEALTH AND HIV/STD PREVENTION IN RURAL SETTINGS (RFA MH-98-004) National Institute of Mental Health

EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION PROJECTS (RFA RR-98-001) National Center for Research Resources

CHEMICAL MIXTURES IN ENVIRONMENTAL HEALTH (RFA ES-98-002) National Institute of Environmental Health Sciences, U.S. Environmental Protection Agency

PREVENTION OF SUICIDAL BEHAVIOR IN OLDER PRIMARY CARE PATIENTS (RFA MH-98-002) National Institute of Mental Health

ROLE OF THE ORAL ENVIRONMENT IN HIV TRANSMISSION AND PATHOGENESIS
(RFA DE-98-007) National Institute of Dental Research, National Institute of Mental Health

NETWORK OF PEDIATRIC PHARMACOLOGY RESEARCH UNITS (RFA HD-98-002)
National Institute of Child Health and Human Development

SPECIALIZED CENTERS OF RESEARCH (SCORs) IN OSTEOPOROSIS, RHEUMATOID ARTHRITIS, AND SCLERODERMA (RFA AR-98-001) National Institute of Arthritis and Musculoskeletal and Skin Diseases

CELLULAR AND MOLECULAR APPROACHES TO ACHIEVING EUGLYCEMIA (RFA DK-98-007) National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Institute on Aging

GLUCOSE SENSORS IN THE TREATMENT OF TYPE 1 DIABETES (RFA DK-98-008)
National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources

PATHOGENESIS AND THERAPY OF COMPLICATIONS OF DIABETES (RFA DK-98-009)
National Institute of Diabetes and Digestive and Kidney Diseases, National Eye Institute, National Heart, Lung, and Blood Institute, National Institute on Aging, National Institute of Dental Research,
National Institute of Neurological Disorders and Stroke

IMMUNOPATHOGENESIS OF TYPE 1 DIABETES MELLITUS (RFA DK-98-010) National Institute of Allergy and Infectious Disease, National Institute of Child Health and Human Development, National Institute of Diabetes and Digestive and Kidney Diseases

PARKINSON'S DISEASE RESEARCH CENTERS OF EXCELLENCE (RFA NS-98-001)
National Institute of Neurological Disorders and Stroke
 

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NIH PROGRAM ANNOUNCEMENTS 
(PA'S): These are ongoing funding priorities, with due dates usually October 1, February 1 and June 1 of each year. Note that HIV-related applications are due January 2, May 1 and September. Past PA's, many of which are still open, can be searched at the NIH Guide web site.
 

SPECIALIZED MENTAL HEALTH INTERVENTIONS RESEARCH CENTERS (PAR-98-020)
National Institute of Mental Health

NATIONAL INSTITUTE ON AGING: PILOT RESEARCH GRANT PROGRAM (PAR-98-021)
National Institute on Aging

SMALL GRANT PROGRAM FOR THE NIDCD (PAR-98-010) National Institute on Deafness and Other Communication Disorders

IMPACT OF HIV VARIATION ON IMMUNOLOGICAL RECOGNITION (PA-98-011) National Institute of Allergy and Infectious Diseases

NEUROSCIENCES TECHNOLOGY DEVELOPMENT (PA-98-012) National Center for Research Resources
 



OTHER OPPORTUNITIES

April 20 (Letter of Intent)
ADDRESSING TOBACCO IN MANAGED CARE, Robert Wood Johnson Foundation

March 31
STOP VIOLENCE AGAINST WOMEN, Illinois Coalition Against Domestic Violence

March 31
VICTIMS OF CRIME ACT, LEGAL ADVOCACY, Illinois Coalition Against Domestic Violence

March 31
VICTIMS OF CRIME ACT, CHILDREN'S SERVICES, Illinois Coalition Against Domestic Violence

February 25
INJURY PREVENTION/CONTROL, Centers for Disease Control and Prevention

February 23
OUTREACH AND RESEARCH SPECIAL EDUCATION SERVICES, Department of Education

Open
BIOMEDICAL ENGINEERING/RESEARCH TO AID PERSONS WITH DISABILITIES, National Science Foundation

Open
HIV/AIDS AWARENESS, Design Industry Foundation for AIDS

April 9
CONSUMER-OPERATED SERVICES FOR PERSONS WITH MENTAL ILLNESS, Substance Abuse and Mental Health Services Administration

March 13
MODEL DEMONSTRATION PROJECTS, Department of Education

March 12
TELECOMMUNICATIONS/INFORMATION INFRASTRUCTURE ASSISTANCE PROGRAM, National Telecommunications and Information Administration

April 1
HIV SERVICE DELIVERY MODELS, Health Resources and Services Administration


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